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| Biliverdin reductase B ： ウィキペディア英語版 |
Biliverdin reductase B
Biliverdin reductase B is a protein that in humans is encoded by the BLVRB gene.
== Structure ==
The BLVRB gene was localized to chromosome 19, the specific region being 19q13.13 to q13.2; this was done using fluorescence in situ hybridization.
BLVRB encodes a protein that is a 206-residue monomeric enzyme. The structure of BVR-B has a single-domain architecture consisting of a central parallel beta-sheet with alpha-helices on either side. This characteristic dinucleotide binding fold comprises, in this case, a seven-stranded parallel beta-sheet further extended by an antiparallel strand. In addition to the seven long strands of the main pleated sheet, a short parallel beta-sheet (strands 6a and 6c) is formed within the loop joining strand 6 and alpha-helix F. The central beta-sheet and the two groups of helices are held together mainly through hydrophobic interactions. One group of helices is made up of alpha-helices C, D and E. The second group is composed of alpha-helices A and F and includes a short 310-helix between strands beta2 and beta3, in contrast to typical dinucleotide binding proteins in which a regular alpha-helix flanks these beta-strands. The most flexible loop in the structure corresponds to loop 120, between strand 5 and alpha-helix E, which contains residues with the highest main chain B-factors, with the exception of the N-terminal region.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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